![]() Our results thus suggest uncoupled mechanisms between acute VOC benefits and the long-term complications of SCD that should be considered in future clinical trials. Mac-1-deletion, however, was not sufficient to reduce SCD-related chronic organ damage. Here, we show that RBC–leukocyte interactions are significantly diminished in Mac-1-deficient SCD mice, leading to an improvement of blood flow rates and prolonged survival time in a tumor necrosis factor-alpha and surgical-trauma-induced VOC model. Emerging evidence suggests that VOC arises from a complex cascade that involves interactions among multiple blood and endothelial cells in the vasculature. Previous studies have identified α Mβ 2 integrin (Mac-1) as a critical molecule that mediates heterotypic interactions between red blood cells (RBCs) and adherent leukocytes and promotes VOC in SCD mice. Recurrent episodes of VOC may cause irreversible organ damage and early mortality in patients with SCD. Google Docs is a service offered by Google to manage web-based documents, like creating, editing Word, Spreadsheets, presentations, even store them online for easy access on different devices. Still uncertain Check out and compare more PDF products. And here we pick 6 best free OCR tools online according to our OCR testing. ![]() ![]() Vaso-occlusive crisis (VOC) is one of the most common complications of sickle cell disease (SCD). Not sure if Adobe Acrobat Reader, or CutePDF is the better choice for your needs No problem.
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